Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance.

Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles or tolerability. Nevertheless, treatment resistance continues to be one of the most pressing unsolved conundrums in cancer treatment. Hypoxia-inducible factors (HIFs) are a family of transcription factors that regulate cellular responses to hypoxia by activating genes involved in various adaptations, including erythropoiesis, glucose metabolism, angiogenesis, cell proliferation, and apoptosis. Despite this critical function, overexpression of HIFs has been observed in numerous cancers, leading to resistance to therapy and disease progression. In recent years, much effort has been poured into developing innovative cancer treatments that target the HIF pathway. Combining HIF inhibitors with current cancer therapies to increase anti-tumor activity and diminish treatment resistance is one strategy for combating therapeutic resistance. This review focuses on how HIF inhibitors could be applied in conjunction with current cancer treatments, including those now being evaluated in clinical trials, to usher in a new era of cancer therapy.

The use-the-best heuristic facilitates deception detection.

Decades of research have shown that people are poor at detecting deception. Understandably, people struggle with integrating the many putative cues to deception into an accurate veracity judgement. Heuristics simplify difficult decisions by ignoring most of the information and relying instead only on the most diagnostic cues. Here we conducted nine studies in which people evaluated honest and deceptive handwritten statements, video transcripts, videotaped interviews or live interviews. Participants performed at the chance level when they made intuitive judgements, free to use any possible cue. But when instructed to rely only on the best available cue (detailedness), they were consistently able to discriminate lies from truths. Our findings challenge the notion that people lack the potential to detect deception. The simplicity and accuracy of the use-the-best heuristic provides a promising new avenue for deception research.